AIP1 in Graft Arteriosclerosis

Tadalafil attenuates graft arteriosclerosis of aortic transplant in a rat model

Objective(s): Tadalafil can restore endothelial function and treat atherosclerosis. However, the effect of tadalafil on transplant arteriosclerosis remains unclear. In this study, we explore the effects of tadalafil on allograft vasculopathy. Materials and Methods: Male Brow-Norway rats supplied aorta grafts for Male Lewis rats. All recipients were divided into 3 groups: saline as placebo (con...

Th1 Adaptive Immune Responses in Cardiac Graft Arteriosclerosis

Heart transplants are not rejected in the absence of adaptive immune responses, eg, in transplantations between genetically identical donors and hosts or to recipients with severe combined immunodeficiencies. Activation of adaptive immunity to an allograft causes destructive responses against donor parenchymal or vascular cells, called acute rejection. In the presence of adequate immunosuppress...

Spontaneous Arteriosclerosis in Rabbits

tadalafil attenuates graft arteriosclerosis of aortic transplant in a rat model

objective(s): tadalafil can restore endothelial function and treat atherosclerosis. however, the effect of tadalafil on transplant arteriosclerosis remains unclear. in this study, we explore the effects of tadalafil on allograft vasculopathy. materials and methods: male brow-norway rats supplied aorta grafts for male lewis rats. all recipients were divided into 3 groups: saline as placebo (cont...

The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis

Data from clinical research and our previous study have suggested the potential involvement of SENP1, the major protease of post-translational SUMOylation, in cardiovascular disorders. Here, we investigate the role of SENP1-mediated SUMOylation in graft arteriosclerosis (GA), the major cause of allograft failure. We observe an endothelial-specific induction of SENP1 and GATA2 in clinical graft ...